Membrane-Initiated Actions of Estrogens in Neuroendocrinology: Emerging Principles
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چکیده
منابع مشابه
Membrane-initiated actions of estrogens in neuroendocrinology: emerging principles.
Hormonal ligands for the nuclear receptor superfamily have at least two interacting mechanisms of action: 1) classical transcriptional regulation of target genes (genomic mechanisms); and 2) nongenomic actions that are initiated at the cell membrane, which could impact transcription. Although transcriptional mechanisms are increasingly well understood, membrane-initiated actions of these ligand...
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BACKGROUND We demonstrated that E2 conjugated to BSA (E2BSA) induces a rapid membrane-initiated inhibition of LH secretion followed hours later by a slight increase in LH secretion. Whether these actions of E2BSA are restricted to the pituitary gland and whether the membrane-initiated pathway of E2BSA contributes to the up-regulation of the number of GnRH receptors during the positive feedback ...
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ژورنال
عنوان ژورنال: Endocrine Reviews
سال: 2007
ISSN: 0163-769X,1945-7189
DOI: 10.1210/er.2005-0021